Jean ButeauJean Buteau, PhD

Office:         5-126B Li Ka Shing Centre for Health Research Innovation
Mail:           University of Ablerta, Edmonton, AB Canada T6G 2E1
Phone:       780-492-8386






Current Position

Associate Professor, Department of Agricultural, Food & Nurtitional Science


Research Area

Pancreatic β-cell mass and function


Current Research Activities


Our reserach efforts are aimed at identifying novel molecular mechanisms that regulate beta-cell mass and function.


To investigate these processes, we use a combination of beta-cell lines, primary human beta-cells and transgenic mice.


Our studies also employ a broad arsenal of techniques encompassing genomic, pharmacological and biochemical analyses to unravel the signals that govern beta-cell differentiation, proliferation and survival.


  • The overall goal is to harness the therapeutic potential of these newly discovered targets to stimulate the generation of new beta-cells and to expand and protect the functional beta-cells that still reside in the pancreas of patients with diabetes.



Dr. Buteau received a PhD in Biochemistry from the University of Montreal under the supervision of Dr. Marc Prentki. His graduate work investigated the action of glucagon-like peptide-1, an intestinal hormone with anti-diabetic properties, on pancreatic β-cell proliferation and survival. After graduating with the highest distinction, Dr. Buteau was awarded a JDRF Fellowship to undertake postdoctoral studies in the laboratory of Dr. Domenico Accili at Columbia University in the City of New York. There, he investigated the prominent role of the transcription factor FoxO1 in the regulation of beta-cell mass and function. In 2008, Dr. Buteau was appointed Assistant Professor at the Department of Medicine of Laval University in Quebec, with support from both the Canadian Diabetes Association and the Quebec Research Funds. Rapidly, Dr. Buteau launched a competitive research program aimed at identifying novel genes that regulate beta-cell birth, life and death. In 2012, Dr. Buteau relocated to Edmonton to join the Alberta Diabetes Institute and the University of Alberta. He is currently Associate Professor at the Department of Agricultural, Food and Nutritional Science.



Anne-Francoise Close, PhD student