Diana MagerDiana Mager, PhD

Office:      4-126 Li Ka Shing Centre for Research Innovation
Mail:        University of Alberta, Edmonton AB T6G 2E1
Phone:    780-492-7687
Fax:        780-492-2011
Email:     mager@ualberta.ca

 

 

 

 

 

Current Position

Assistant Professor, Clinical Nutrition

Department of Agriculture, Food and Nutritional Science

Department of Pediatrics

 

Research Area

 

Areas of interest include the study of the vitamin D and K intake and bone health and the impact of oxidative stress on nutrient metabolism in diabetes, chronic liver and gastrointestinal disease in children and adults.  Current studies focus on the dietary and metabolic characteristics influencing the pathogenesis of chronic liver disease (eg nonalcoholic fatty liver disease, parenteral nutrition induced liver disease) in these populations. Research focused on treatment strategies (including nutrition support interventions, lifestyle modification), patient outcomes and evidence-based clinical dietetic practice will be examined. Teaching responsibilities relate to introductory and advanced clinical nutrition and research focused on nutrition support strategies in clinical dietetic practice.

 

 

Current Research Activities

 

Human Research

1) Vitamin D Supplementation and Bone Health in Adults with Diabetic Nephropathy.

Study Synopsis: Investigation of the effect of two different vitamin D supplementation (monthly vs daily) and its effects overall vitamin D status, bone health and quality of life in adults (19-75 yrs) with both diabetes and kidney disease (stage 1-4).

 

Status: Subject recruitment on-going.  Contact Personnel:

Stephanie Schwindt RD: 780-901-8990/sts5@ualberta.ca

Ping Li RD: 780-709-6321/pingl@ualberta.ca

 

2) Effect of Branched Chain Amino Acid Supplementation in Infants with Cholestatic Liver Disease on neurodevelopmental and growth outcomes.

Investigation of the effect of branched chain amino acid supplementation on growth and neurodevelopmental outcomes in infants (2-12 months) with cholestatic liver disorders pre-liver transplantation.

Status: Subject recruitment to Start Fall of 2012.

Contact Personnel: Cheri Robert MSc 780-248-5611

Cheri.robert@albertahealthservices.ca

 

 

3) FRAGILE: Impact of lifestyle intervention in nonalcoholic fatty liver disease in children (FRAGILE: Fructose, activity and glycemic index intervention in liver disease).

Nutrition and physical intervention study examining the efficacy of lifestyle modification on liver function, body composition in both healthy children and in children with chronic liver disease.

Status: Ongoing subject recruitment. Children between the ages of 4-18years of age with liver disease and healthy children are being recruited for this study.

Contact Personnel: Diana Mager PhD RD; mager@ualberta.ca

780-492-7687.

 

4) Fat metabolism in children with non-alcoholic fatty liver disease (NAFLD)

Investigation of the interrelationships between dietary intake and how this contributes to fat metabolism in children and adolescents (4-18 yrs) with NAFLD.

Status: Ongoing subject recruitment. Both healthy children and children with NAFLD are being recruited for this study.

Contact Personnel: Diana Mager PhD RD: mager@ualberta.ca

780-492-7687,

 

5) Dietary intakes in children who have undergone liver transplantation.

Investigation of dietary intakes in children (2-18 yrs) who have undergone liver transplantation.  Focus of study is on vitamin K/calcium and vitamin D intakes and how this might influence overall bone health in both healthy children and in children who have undergone liver transplantation.

Status: Ongoing subject recruitment.

Contact Personnel: Cheri Robert MSc: 780-248-5611.

Cheri.robert@albertahealthservices.ca

Abeer Alzaben MSc (candidate): 780-695-8830

alzaben@ualberta.ca

 

6) Does the gluten free diet meet the nutritional needs of children and adolescents with Celiac Disease?

Focus of study is on vitamin K/calcium and vitamin D intakes and how this might influence overall bone health and quality of life in both healthy children and in children who have been diagnosed with Celiac Disease.

Status: Ongoing subject recruitment;

Contact Personnel: Abeer Alzaben MSc (candidate): 780-695-8830

alzaben@ualberta.ca

 

7) Exploring Parent's knowledge, attitudes and beliefs about nutrition education in children and adolescents with nonalcoholic fatty liver disease (NAFLD).

Investigation of the impact of parental knowledge about nutrition and how this influences the ability of the child, parent and family to follow nutritional advice. Parents of healthy children and children with chronic liver disease are being recruited into these studies.

Status: Ongoing subject recruitment.

Contact Personnel: Ingrid Rivera MSc (candidate): irivera@ualberta.ca

Other Activities & Affiliations

  • Associate Editor, J Applied Physiology, Nutrition & Metabolism, 2008-present.
  • Member of the Editorial Board, Journal of the Academy of Nutrition & Dietetics: 2009-present.
  • Research Committee, American Society of Parenteral and Enteral Nutrition, USA. June 1, 2010-present
  • Council Member (Governing Council), College of Dietitians of Alberta, September 2009-present.
  • National Educational Advisory Committee,  Canadian Liver Foundation: Nutrition Expert.  2008-present
  • Publications Committee, Canadian Nutrition Society, 2011-present.
  • Practice-based Evidence in Nutrition [PEN] Advisory Committee, Dietitians of Canada, 2012-present
  • Licensure: College of Dietitians of Alberta (RD), Academy of Nutrition and Dietetics/Commission of Dietetic Registration (RD).
  • Active & ongoing Professional Membership(s): A.S.P.E.N, Dietitians of Canada, Can Association of Gastroenterology, Canadian Nutrition Society.

 

 

Major Achievements

 

      

Mager DR, Yap J, Rodriguez-Dimitrescu C, Mazurak V, Ball G.D, Gilmour SM. Anthropometric measures of visceral and subcutaneous fat are important in the determination of metabolic dysregulation in boys and girls at risk for nonalcoholic fatty liver disease. Nutr Clin Prac 2012 (in press). DOI: 10.1177/0884533612454884

Schwindt ST,  Hubert G, Koh A, Shapiro AMJ, Senior PA, Mager DR. Evaluation of bone health in adults undergoing Islet Transplantation. Can J Diabetes  2012 (accepted June 2012)

Seida, J, Mager DR,  Hartling L, Vandermeer  B, Turner JM. Parenteral n-3 Fatty Acid Lipid Emulsions for Children with Intestinal Failure and Other Conditions: A Systematic Review.  JPEN, 2012 (on line in advance of publication June 8 2012). doi:10.1177/0148607112450300

Mager DR, Qiao J, Turner JM. Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with Celiac Disease. Eur J Clin Nutr  2012:66:488-495

Mager DR, Patterson C, So S, Rogenstein C, Wykes LJ, Roberts EA.  Dietary and physical activity patterns in children with fatty liver. Eur J Clin Nutr 2010; 64: 628-635,

Mager DR, Marcon, M, Wales, P, Pencharz PB. Use of N-acetyl cysteine for the treatment of parenteral nutrition (PN) induced liver disease in children on home PN J Pediatr Gastr Nutr.2008:46(2):220-223;

Mager DR, Wykes LJ, Roberts EA, Ball RO & Pencharz PB. Effect of orthotopic liver transplantation on total branched chain amino acid requiremenst. Ped Res 2006; 59(6):829-834

Mager DR, McGee P, Furuya KN, Roberts EA. Prevalence of vitamin K deficiency in children with mild to moderate chronic liver disease. JPGN:2006; 42(1):72-76.

Mager DR, Roberts EA. Non-alcoholic fatty liver disease in children.  Clin Liver Dis 2006:10 (1): 109-131.

Mager DR, Wykes LJ, Roberts EA, Ball RO & Pencharz PB.  Total branched chain amino acid needs in children with mild to moderate chronic cholestatic liver disease.  J Nutr  2006:136 (1);133-139

 

Current Trainees:

Stephanie Schwindt RD (MSc candidate): 2011-present: Vitamin D Supplementation and Bone Health in Adults with Diabetic Nephropathy.

Abeer Al-zaben MSc candidate: 2011-present:  Vitamin D/K intakes and bone health in children who have undergone liver transplantation.

Carla Rodriguez Dimitrescu PhD candidate: 2007-present.  Effect of acute intakes of high saturated fat intakes on postprandial metabolic metabolism in children and adolescents with non-alcoholic fatty liver disease.

Ingrid Rivera MSc candidate: 2011-present. Effect of a dietary intervention (FRAGILE) on body composition and liver function in children and adolescents with non-alcoholic fatty liver disease.

Ping Li: MSc candidate: 2012-present. Vitamin D and K intakes in adults with diabetes and kidney disease (co-supervised P. Senior MD).

Naajla Al-Thobaity MSc candidate: 2010-present: Vitamin D and calcium intakes in children with celiac disease.