Scot SimpsonScot Simpson, BSP, PharmD, MSc

Office:     3-205, Edmonton Clinic Health Academy
Mail:       University of Alberta, Edmonton AB T6G 2R3
Phone:    780-492-7538
Fax:        780-492-1217





Current Position

Associate Professor, Faculty of Pharmacy & Pharmaceutical Sciences

Research Area


Health outcomes associated with medications used for diabetes management.  Medication adherence – determinants; interventions to improve; and health outcomes.


Research Synopsis

My research program follows the role of pharmacists and how they can help optimize medication management of diabetes and its complications.  Current research topics include:


  • Measuring the impact of adding a pharmacist to family medicine clinics to help optimize medication management of cardiovascular risk in type 2 diabetes;


  • Quantifying the effect of medication adherence on health outcomes;


  • Evaluating the effectiveness and safety of various oral antidiabetic regimens using population health datasets; and


  • Identifying patient-perceived barriers to optimal medication use.



Patient compliance, pharmacoepidemiology, pharmacy services, health outcomes

Selected Publications

Abdelmoneim AS, Hasenbank SE, Seubert JM, Brocks DR, Light PE, Simpson SH. Variations in tissue selectivity amongst insulin secretagogues: a systematic review. Diab Obseity & Metab 2012;14:130-8.


Omran D, Guirguis LM, Simpson SH. Systematic review of pharmacist interventions to improve adherence to oral antidiabetic medications in people with type 2 diabetes. Can J Diabetes 2012;36:292-9.

Simpson SH, Majumdar SR, Tsuyuki RT, Lewanczuk RZ, Spooner R, Johnson JA. Effect of adding pharmacists to primary care teams on blood pressure control in patients with type 2 diabetes: a randomized controlled trial (ISRCTN97121854). Diabetes Care 2011;34:20-6.


Simpson SH, Gamble JM, Mereu L, Chambers T. Effect of aspirin dose on mortality and cardiovascular events in people with diabetes: a meta-analysis. J Gen Intern Med 2011;26:1336-44.


Law E, Simpson SH. Aspirin use rates in diabetes: a systematic review and cross-sectional study. Can J Diabetes 2010;34:211-7.


Gamble JM, Simpson SH, Brown LC, Johnson JA. Insulin versus an oral antidiabetic agent as add-on therapy in type 2 diabetes after failure of an oral antidiabetic regimen: a meta-analysis. Open Medicine 2008;2(2):E1-13.


McLean D, Simpson SH, McAlister FA, Tsuyuki RT. Treatment and blood pressure control in 47,964 people with diabetes and hypertension: a systematic review of observational studies. Can J Cardiol 2006;22:855-60.


SH Simpson, DT Eurich, SR Majumdar, R Padwal, RT Tsuyuki, J Varney, JA Johnson. A meta-analysis of the association between drug therapy adherence and mortality. Brit Med J. 333:15-9, 2006.


JR Shiu, SH Simpson, JA Johnson, RT Tsuyuki. Opportunities to affect diabetes management in the community. Can Pharm J. 139(3):37-8, 2006.

SH Simpson, SR Majumdar, RT Tsuyuki, DT Eurich, JA Johnson. The dose-response relationship between sulfonylureas and mortality in type 2 diabetes: a population-based cohort study. Can Med Assoc J. 174:169-74, 2006.


DT Eurich, SH Simpson, SR Majumdar, JA Johnson.  Secondary failure rates associated with metformin and sulfonylurea therapy for type 2 diabetes mellitus.  Pharmacotherapy. 25:810–816, 2005.

JA Johnson, SH Simpson, EL Toth, SR Majumdar. Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes. Diabet Med. 22:497-502, 2005.


SH Simpson, JA Johnson, RS Biggs, RT Tsuyuki, for the SCRIP Investigators. Greater effect of enhanced pharmacist care on cholesterol management in patients with diabetes mellitus: a planned subgroup analysis of the Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP). Pharmacotherapy. 24:389-394, 2004.

JA Johnson, SR Majumdar, SH Simpson, EL Toth. Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes. Diabetes Care. 25:2244-8, 2002.

SH Simpson, JA Johnson, C Biggs, RS Biggs, A Kuntz, W Semchuk, JG Taylor, KB Farris, RT Tsuyuki, for the SCRIP Investigators. Practice-based research: lessons from community pharmacist participants. Pharmacotherapy. 21:731-9, 2001.

Faculty of Pharmacy and Pharmaceutical Sciences