Richard Lehner, PhD
Office: 315 HMRC
Mail: Room 328 HMRC, University of Alberta, Edmonton, AB T6G 2S2
Phone: 780-492-2693 (Office)
Director, Group on Molecular and Cell Biology of Lipids
Professor, Dept. of Pediatrics
Adjunct Professor, Dept. of Cell Biology
Fatty liver, obesity, insulin resistance
Fat absorption, cholesterol metabolism, atherosclerosis
Lipid droplet dynamics
Current Research Activities
Triacylglycerol (TG, also commonly referred to as fat) is the most concentrated form of energy storage in humans. Excessive TG storage is manifested as obesity, which is a major health problem in the Western world. Obesity is a risk factor for hypertension, diabetes and cardiovascular disease. Therefore, there is a substantial pharmaceutical interest in the enzymes that control TG metabolism in tissues. Our research is focused at elucidating the mechanism by which TG is utilized in the liver, intestine, adipose and other tissues.
Dr. Lehner obtained his PhD in Biochemistry at the University of Toronto, followed by post-doctoral training at the CNRS in Marseille, France and at the University of Alberta. He joined the Department of Pediatrics at the University of Alberta as an Assistant Professor in 1998 with cross-appointment in the Dept. of Cell Biology. In 2008 Dr. Lehner was appointed Director of the Group on Molecular and Cell Biology of Lipids.
- A.D. Quiroga, L. Lian and R. Lehner. (2012) Carboxylesterase1/esterase-x regulates chylomicron production in mice. PLoS One
- J. Lian, A.D. Quiroga, L. Li, and R. Lehner. (2012) Ces3/TGH deficiency improves dyslipidemia and reduces atherosclerosis in Ldlr-/- mice. Circ. Res.
- A.D. Quiroga, L. Li, M. Trötzmüller, R. Nelson, S.D. Proctor, H. Köfeler, and R. Lehner. (2012) Deficiency of Carboxylesterase1/Esterase-x in mice results in obesity, hepatic steatosis and hyperlipidemia. Hepatology
- J. Lian, E. Wei, S. Wang, A.D. Quiroga, L. Li, A. Di Pardo, J. van der Veen, S. Sipione, G.A. Mitchell and R. Lehner. (2012) Liver specific inactivation of Ces3/TGH decreases blood lipids without causing severe steatosis. Hepatology
- R. Lehner, J. Lian and A.D. Quiroga. (2012) Lumenal lipid metabolism: Implications for lipoprotein assembly. Arterioscler. Thromb. Vasc. Biol.
- A.D. Quiroga and R. Lehner. (2011) Role of endoplasmic reticulum neutral lipid hydrolases. Trends Endocrinol. Metab.
- H. Wang, E. Wei, A.D. Quiroga, X. Sun, N. Touret and R. Lehner (2010) Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression. Mol. Biol. Cell
- E. Wei, Y. Ben Ali, J. Lyon, H. Wang, R. Nelson, V.W. Dolinsky, J.R. Dyck, G.A. Mitchell, G. S. Korbutt and R. Lehner (2010) Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance and increases energy expenditure. Cell Metab.
- V. Lo, B. Erickson, M. Thomason-Hughes, K.W.S. Ko, V.W. Dolinsky, R. Nelson and R. Lehner (2010) Arylacetamide deacetylase attenuates fatty acid-induced triacylglycerol accumulation in rat hepatoma cells. J. Lipid Res.
The Group on the Molecular & Cell Biology of Lipids
Department of Cell Biology profile