Jason Dyck, PhD
Lab: 430 Heritage Medical Research Centre
Office: 458 Heritage Medical Research Centre
Mail: University of Alberta, Edmonton, AB T6G 2S2
Phone: 780-492-0314 (Office)
Professor, Department of Pediatrics
Director, Cardiovascular Research Centre
Co-Director, Alberta HEART
AHFMR Senior Scholar
Dr. Dyck is a Professor in the Department of Pediatrics and the Director of the Cardiovascular Research Centre at the University of Alberta. He is also the co-director of the Alberta HEART, which is a province-wide program aimed at understanding and treating diastolic heart failure.
Dr. Dyck has a broad area of research that includes the study of skeletal muscle insulin resistance, hypertension, cardiac hypertrophy, ischemia/reperfusion injury, diabetic cardiomyopathy and chemotherapy-induced cardiotoxicity. These diverse research topics are linked by Dr. Dyck’s interest in how alterations in energy metabolism contribute to these diseases.
Current Research Activities
Since establishing his independent research program, Dr. Dyck has published a number of important studies that have had a significant impact on the area of cardiac energy metabolism and have contributed to the understanding of the pathogenesis of heart defects associated with altered cardiac energetics.
Sung MMY and Dyck JRB and. Age-related cardiovascular disease and the beneficial effects of calorie restriction. Heart Failure Reviews. 2012 (in press).
Kok BPC, Kienesberger PC, Dyck JRB, Brindley DN. Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice. J Lipid Res. 2012;53(1):105-18.
Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JRB. Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol. 2012;32(4):740-50.
Ussher JR, Wang W, Gandhi M, Keung W, Samokhvalov V, Oka T, Wagg CS, Jaswal JS, Harris RA, Clanachan AS, Dyck JRB, Lopaschuk GD. Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury. Cardiovasc Res. 2012;94(2):359-69.
Bourque SL, Dolinsky VW, Dyck JR, Davidge ST. Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia. Placenta. 2012;33(5):449-52.
Breen DM, Dolinsky VW, Zhang H, Ghanim H, Guo J, Mroziewicz M, Tsiani EL, Bendeck MP, Dandona P, Dyck JRB, Heximer SP, Giacca A. Resveratrol Inhibits Neointimal Formation After Arterial Injury Through an Endothelial Nitric Oxide Synthase-Dependent Mechanism. Atherosclerosis. 2012;222(2):375-81.
Dolinsky VW, Jones KE, Sidhu RS, Haykowsky M, Czubryt MP, Gordon T, Dyck JRB. Improvements in Skeletal Muscle Strength and Cardiac Function Induced by Resveratrol Contribute to Enhanced Exercise Performance in Rats. J Physiology. 2012;590(Pt11):2783-99
Jones LW, Antonelli J, Masko EM, Lascola CD, Fels D, Dewhirst MW, Dyck JRB, Nagendran J, Flores CT, Betof AS, Young ME, Nelson ER, Pollak M, Broadwater G, Freedland SJ. Exercise Modulation of the Host – Tumor Interaction in an Orthotopic Model of Murine Prostate Cancer. J Appl Phys. 2012;113(2):263-72.
Rueda-Clausen CF, Morton JS, Dolinsky VW, Dyck JRB, Davidge ST. Synergistic effects of prenatal hypoxia and postnatal high fat diet in the development of cardiovascular pathology in young rats. Am J Physiol Regul Integr Comp Physiol. 2012;303(4):R418-26.
Nagendran J, Waller TJ, Dyck JRB. AMPK Signalling and the Control of Substrate Use in the Heart. Mol Cell Endocrinol. 2012 (in press).
Kienesberger PC, Pulinilkunnil T, Dyck JRB. Myocardial Triacylglycerol Metabolism. JMCC 2012 (in press).
Kandasamy AD, Sung MM, Dyck JRB. Adiponectin gene therapy ameliorates high-fat, high sucrose diet-induced metabolic perturbations in mice. Nutrition & Diabetes. 2012. (in press).
Chung JH, Manganiello V, Dyck JRB. Resveratrol as a calorie restriction mimetic: therapeutic implications. Trends Cell Biol. 2012 (in press).
Dr. Shereen Hamza
Dr. Petra Kienesberger
Dr. Jeevan Nagendran
Ms. Carrie-Lynn Soltys
Ms. Miranda Sung
Dr. Beshay Zordoky