Islet Mass Regeneration During Pregnancy

Dr. Edmond Ryan

Edmond RyanIslet Mass in pregnant Type 1 diabetes – traditionally it was felt that people with Type 1 diabetes had no surviving insulin secreting cells but this has now been shown to be incorrect.  Pregnancy may be an ideal opportunity for some regeneration of beta cells given the relatively immune suppression associated with pregnancy and the ongoing excellent glycemic control that is typically striven for during pregnancy.  We are measuring C-peptide secretion after arginine in women with type 1 diabetes during the course of pregnancy in post partum to see if we can document if there is any recovery of beta cell function.  Demonstration of such recovery could open the door for further research in the area of regeneration of islets in people with type 1 diabetes.

Status: ongoing