Overview - Clinical Research Studies

Below is a summary of the clinical trials pipeline in the our Clinical Research Unit.  

If you would like to participate in any of the actively recruiting trials visit Participate in a Research Study. Volunteering for clinical trials may someday benefit you or someone you know since you will be contributing to the development of the new and innovative treatments being investigated at the Alberta Diabetes Institute.

Upcoming Clinical Trials

Biomedical Intervention Trials

 Investigator/Sponsor

Disease

Phase

Trial Type

 Andrea Haqq/OPKO Growth hormone deficiency in children  Efficacy and safety of a longer-acting growth hormone 
 Peter Senior/ProMetic  Type 2 diabetes with metabolic syndrome  Efficacy and safety of the drug PBI-4050


Nutrition

 



Physical Activity

  Normand Boulé  Type 2 diabetes - Aerobic Exercise

Recruiting Clinical Trials


 Biomedical Intervention Trials

 Investigator/Sponsor

 Disease

Phase or title

 Trial Type

 Peter Senior/Sanofi Type 1 diabetes   4  Efficacy of a longer-acting basal insulin
 Peter Senior
 /Novo Nordisk
 Newly diagnosed Type 1 diabetes Effect of a combination of two drugs (NNC0114-006 and liraglutide) on preservation of beta cell function


Nutrition (recruiting)

 Fatheema Subhan
 Cathy Chan
 Healthy Digestibility and functional benefits of isomalto – oligosaccharides (IMO) Study - Arm2  Intervention 
 Donna Vine  Polycystic Ovary Syndrome Polycystic Ovary Syndrome Clinical Trial  Intervention 
  Diana Mager Diabetic Nephropathy
Vitamin D supplementation and bone health in adults with diabetic neuropathy: a 2 year follow up study Intervention
  Diana Mager Celiac Disease
Quality of Life and Dietary Adherence to the Gluten Free Diet in Children with Celiac Disease   Observational
  Diana Mager Celiac Disease  Adherence to Vitamin Supplementation in Celiac Disease
Observational 
  Diana Mager Non-Alcoholic Fatty Liver Disease   Dietary Fructose as a Mediator to Altered hepatic Energy Metabolism Intervention 
  Diana Mager Non-Alcoholic Fatty Liver Disease   Altered Fat Metabolism as a Mediator to Non Alcoholic Fatty Liver Disease (NAFLD)  Intervention
  Diana Mager End Stage Liver Disease Awaiting Transplantation (infants)  Effects of Branched Chain Amino Acid (BCAA) Supplementation on Growth and Neurodevelopment  Intervention
  Andrea Haqq Pediatric Prader-Willi Syndrome and Healthy Controls Nervous system function in children and teens Observational 
  Jens Walter Healthy overweight men and women  The Alberta FYBER Study (Feed Your Gut Bacteria More FIber) Intervention 
 Carla Prado Advanced colorectal cancer patients Protein Recommendations to Increase Muscle (PRIME)  Intervention 
 Carla Prado Newly diagnosed, treatment naive cancer patients with solid tumors  Resting Energy Expenditure in Cancer: Associations with Body Composition, Dietary Intake, and Exercise Habits Observation 
 
Physical Activity (recruiting)

 Jane Yardley  T1D Effects of physical fitness on glycemic responses to high intensity exercise 
Observation 

 
 Jane Yardley T1D  Blood Glucose Responses to Resistance Exercise in Type 1 Diabetes 
Observation 

 
 Jane Yardley Healthy participants matching islet transplant participants  The Impact of Exercise on Blood Glucose
in Islet Transplant Recipients 
Observation 
  Margie Davenport Postpartum women  - Observational
  Margie Davenport
Pregnant women
- Observational 
  Margie Davenport Pregnant women   - Observational
 Jorden Rees Type 2 Diabetes  Exercise-Physical Activity Diabetes Glucose Monitoring (E-PAraDiGM) Protocol   

Ongoing Clinical Trials (not recruiting) 


 Biomedical Intervention Trials

 Investigator/Sponsor

 Disease

Phase

 Trial Type

  Peter Senior /
  Joslin Diabetes Institute
 Type 1 diabetes with kidney disease  drug
 Peter Senior/Bristol-Myers Squibb Type 1 diabetes   3  Efficacy and safety of the drug Dapagliflozin
  Raj Padwal / 
  Valencia
Refractory hypertension   -  device
  Alicia Chan/Replagal Fabry disease
 -  drug

  Alicia Chan /
  CFDI Data Registry

Fabry disease 

-

registry 

  Peter Senior / ProMetic  Type 2 diabetes with Metabolic Syndrome  drug
 Peter Senior /
 Novo Nordisk
Type 1 diabetes   3b Efficacy and safety of a faster-acting insulin when used in an insulin pump 


Nutrition

 Fatheema Subhan Role of fiber in gut health Digestibility and functional benefits of isomalto-oligosaccharides (IMO) study Observation
 Rhonda Bell /
 Alberta Pulse Growers

Elevated Cholesterol

Beans & Peas  Dietary Intervention
 Diana Mager
Diabetic Nephropathy
- Intervention
 Carla Prado  Post-Partum Women Observation 
 Rhonda Bell  Pregnant Women Intervention 
 Cathy Chan Type 2 Diabetes  Intervention 


Physical Activity

       

Completed Trials


 Biomedical Intervention Trials (completed)

 
Investigator/Sponsor 

 Disease

Phase

 Trial Type / Phase

 Peter Senior/Servier Type 2 diabetes with kidney disease   2 drug 
  Raj Padwal /
  Novo Nordisk
Type 2 diabetes  3a  drug

  Mary Jetha,
  Andrea Haqq / Merck

Type 2 diabetes

3

drug

  Peter Senior /
  Novo Nordisk


Type 1 diabetes
3a drug
  Peter Senior /
  Novo Nordisk
Type 1 diabetes   3a drug 
  Peter Senior /
  AstraZeneca
Type 2 diabetes with cardiovascular
disease 
 3 drug
  Raj Padwal /
  Novo Nordisk
 Obesity  3 drug


Nutrition

 
 Cathy Chan 

Type 2 diabetes n/a Nutrition
  L. McCargar /
 Alberta Diabetes  Institute
Type 2 diabetes  n/a Metabolic 
assessment
  L. McCargar / 
 Alberta Diabetes  Institute
Type 2 diabetes  n/a  Metabolic 
assessment
  L. McCargar / 
 Alberta Diabetes  Institute
Healthy volunteers  n/a   Metabolic 
assessment
 
Physical Activity

 Jane Yardley  Type 2 diabetes Impact of Exercise on Blood Glucose
in Islet Transplant Recipients